QSAR and 3D-QSAR in Drug Design Anti-Tubercular Drug Discovery Studies

The relationships between lipophilicity and unspecific biological properties, such as narcotic, fungicidal, bactericidal, hemolytic and toxiccity properties have been known ever since the turn of the century. Research publications of Free Wilson method [1] and that of Hansch analysis [2] during 1964 served as the milestones in development of quantitative structure-activity relationships (QSAR). Later, introduction of Hansch and Free Wilson models enabled the pharmaceutical chemists to formulate hypotheses of structure-activity relationships quantitatively for checking these hypotheses by means of statistical models.